Ultimate Spider-Man (2000) #87
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Characters
Mary Jane Watson was the guiding light in Peter Parker's life, and their love had overcome countless obstacles.
Silver Sable trained her entire life, becoming a master of a wide variety of weapons and training in all forms of hand-to-hand combat in preparation for the day she would inherit leadership of the Wild Pack.
Peter’s relatively normal life changed abruptly during a school trip to Osborn Industries, Inc, where the company had been working on a super soldier serum, the Oz Compound; a spider exposed to it escaped and bit Peter before it was destroyed.