Thing (1983) #22
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The radiation that mutated Reed Richards, Sue Storm and Johnny Storm into superhuman beings had also mutated Ben Grimm, transforming him into a grotesque, rock-hided strongman dubbed the Thing.
Arguably the greatest and certainly the most horrific creation of scientific genius Dr. Henry Pym, Ultron is a criminally insane rogue sentient robot dedicated to conquest and the extermination of humanity.